Associate Director Bioanalysis and Biomarkers

Associate Director Bioanalysis and Biomarkers

Cambridge, UK

Salary & Benefits Competitive

Meaningful Impact. Make a more meaningful contribution Impact patients’ lives every day

Make a more meaningful impact in your career, with greater ownership and accountability to make a contribution. And in return… we’re looking for people driven by making a difference to patients’ and society, dedicated to doing the right thing.

As a community of professionals, we welcome innovation in all its forms. From breakthrough medicines to production efficiencies, each new step forward reveals the potential of what science can do.

Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions.

We are seeking a highly motivated Associate Director to join the integrated bioanalysis organisation. The position will take a lead role in the lab designing bioanalysis method strategies and interpreting data generated in support of new modality projects that will advance our drug pipeline. This is a scientific leadership role providing bioanalysis strategic direction to the organisation. The position also requires working as the group representative in multidiscipline drug discovery teams where effective interactive communication and provision of influential bioanalysis advice is essential.

The position is in our Discovery Bioanalysis Europe team which is part of the Clinical Pharmacology and safety sciences function and is responsible for the analysis of nucleotide, protein, monoclonal antibody and gene and cell therapeutics and non-clinical safety biomarkers in biological and invitro samples generated in support of non GLP pharmacokinetic, pharmacodynamic and investigational safety studies. We have a diverse array of scientists working across many technologies to ensure delivery of critical assays and data analysis that drive go/no go decisions and ensure the right combination of medicines get to the right patient, in the right dose, at the right time

What you’ll do

  • Using a range of innovative analytical methodologies, this position will work to develop novel methods for the pharmacokinetic measurement of therapeutic gene editing, protein and nucleotide therapeutics.
  • Your principle responsibility will be in the lab, designing, developing, and interpreting assays and data to support discovery drug program transition through to lead candidate selection.
  • You will be expected to represent the department on multidiscipline drug discovery teams spanning a number of different therapeutic modalities, thus ability to utilise a range of technologies in the lab will be essential such as large molecule by HPLC-MS/MS, PCR, ligand binding, branched-DNA and hybridisation ELISA.
  • You will report into a head of Discovery Bioanalysis EU and be expected to take a lead role in pushing the boundaries of what is possible for new modality therapeutics bioanalyses.

Essential for the role

  • A strong background in a biological or chemical related discipline with extensive experience of developing methods for the quantitative measurement of biotherapeutics such as therapeutic gene editing, nucleotides, antibodies and proteins using technologies such as PCR, ligand binding, branched-DNA and hybridisation ELISA.
  • A high level of independence and with an ability to develop hypotheses and execute analysis plans for pharmacokinetics, pharmacodynamics and biomarker data.
  • Attention to detail, good communication, and collaboration skills. Outstanding record keeping skills are critical for success.
  • An ability to think and act creatively- independently, and within collaborations.
  • Experience with data analysis tools for analysing and visualizing pharmacokinetic and biomarker data.

Desirable for the role

  • A proven track record of publication in large molecule, gene editing and / or bioanalysis field. Innovative and influential leader, capable of developing strategic approaches to analytical challenges

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date.

This role is open from 08/02/2022, we welcome your application no later than 10/03/2022

Where can I find out more?

Follow AstraZeneca on LinkedIn

Follow AstraZeneca on Facebook

Follow AstraZeneca on Instagram

Privacy Policy / BBSTEM Limited | Registered in England and Wales | Company No: 11127036