Associate Director, Immunotoxicology

In this key role, you will apply your existing immunology problem-solving expertise alongside that of the collective team to develop innovative strategies to understand and mitigate unwanted immune-mediated adverse reactions to RNA therapeutics and the nuances of nanoparticle delivery systems.

This will include investigation of immunological inter and intra-cellular pathways to afford mechanistic understanding across multiple organs, working closely with safety scientists in other areas of expertise to fully understand the safety profile.

You should be able to seek-out and deploy diverse areas of immune knowledge into coherent strategies and bespoke investigations in order to address the key immune issues for mRNA and nanoparticle systems. This will involve initiating collaborations with academic teams externally to access the leading scientific knowledge in the field.

You will be responsible for providing expert advice on the immunotoxicology strategy for RNA therapies and delivery systems to safety representatives on project teams whilst leading problem-solving activities using in vitro and ex vivo models.

This role will involve close interactions with many other AZ scientists and collaborators in a highly international environment. You will be expected to continuously develop your immunotoxicology expertise and scientific network, regularly presenting our innovative science through peer-reviewed publications and presentations at selected scientific conferences. This will enable you to influence our Immunotoxicology safety strategy, develop our technical problem-solving capabilities, and enhance our external scientific reputation.

You should be highly motivated, innovative, meticulous, creative, well organised and able to work independently and collaboratively when designing and performing experiments and will be expected to lead and prioritise multiple projects and tasks in line with the objectives of the Immunotoxicology and RNA therapy project teams.

Associate Director, Immunotoxicology

Cambridge, UK

Competitive Salary & Benefits

Make a more meaningful impact to patients’ lives around the globe

With our ground-breaking pipeline, the outlook is bright. Be proud to be part of a place that has achieved so much, yet is still moving forward. There’s no better time to join our global, growing enterprise as we lead the way for healthcare and society.

Make a difference in a UK business that changes lives every day.

With deep roots and a proud heritage, AstraZeneca UK is a well-known brand and respected company, with a strong reputation in both the scientific community and academia.

Follow the science to explore and innovate

Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world’s most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world.

This is an opportunty to join our Immunotoxicology Team to help drive the development of safe and innovative RNA therapies and associated delivery systems to improve patients’ lives.

Safety Innovation (SI) is a global department sited within the Safety Sciences arm of Clinical Pharmacology and Safety Sciences (CPSS) function, where application of innovative science drives the design, selection and development of safer medicines. We collaborate with other departments both within and external to CPSS on novel drug programmes from early discovery through to clinical development. We work with a wide range of drug modalities targeting a number of disease indications.

Our Immunotoxicology team uses cutting edge platforms and in vitro/ex vivo models to develop bespoke solutions to address potential immune safety questions across a wide portfolio.

What you’ll do:

In this key role, you will apply your existing immunology problem-solving expertise alongside that of the collective team to develop innovative strategies to understand and mitigate unwanted immune-mediated adverse reactions to RNA therapeutics and the nuances of nanoparticle delivery systems.

This will include investigation of immunological inter and intra-cellular pathways to afford mechanistic understanding across multiple organs, working closely with safety scientists in other areas of expertise to fully understand the safety profile.

You should be able to seek-out and deploy diverse areas of immune knowledge into coherent strategies and bespoke investigations in order to address the key immune issues for mRNA and nanoparticle systems. This will involve initiating collaborations with academic teams externally to access the leading scientific knowledge in the field.

You will be responsible for providing expert advice on the immunotoxicology strategy for RNA therapies and delivery systems to safety representatives on project teams whilst leading problem-solving activities using in vitro and ex vivo models.

This role will involve close interactions with many other AZ scientists and collaborators in a highly international environment. You will be expected to continuously develop your immunotoxicology expertise and scientific network, regularly presenting our innovative science through peer-reviewed publications and presentations at selected scientific conferences. This will enable you to influence our Immunotoxicology safety strategy, develop our technical problem-solving capabilities, and enhance our external scientific reputation.

You should be highly motivated, innovative, meticulous, creative, well organised and able to work independently and collaboratively when designing and performing experiments and will be expected to lead and prioritise multiple projects and tasks in line with the objectives of the Immunotoxicology and RNA therapy project teams.

Essential Criteria:

  • Bachelors degree or equivalent qualification in an appropriate subject area (immunology, cell biology, molecular biology)
  • A PhD in an immunology field or substantial equivalent industrial experience in the field of immunology.
  • Knowledge and practical experience in the field of immunology/immunotoxicology and an understanding of the potential adverse outcomes of immune modulation, experience within the mRNA field an advantage.
  • Extensive flow cytometry and primary cell culture experience
  • In depth theoretical understanding and practical experience of in vitro and ex vivo cell-based assays systems utilising immortalised cell lines and primary tissues.
  • Experience in leading hypothesis-led strategic investigation
  • Extensive experience in collation, interpretation and communication of complex data
  • Ability to work both independently and within a team environment, supporting colleagues and open to support in return as required.
  • Confidence in communicating findings globally both internally and externally through oral and written forms in a clear and precise manner.
  • Strong scientific leadership, evidenced by a recent publication track record or evidence of the ability to independently lead the drafting and review of publication manuscripts
  • Willingness to challenge conventional thinking and implement creative ideas balanced with a high regard and understanding for the regulatory framework in which AstraZeneca operates is expected
  • Ability to follow Good Laboratory Science standards, Safety, Health and Environment standards and other relevant external regulation.

Desirable Criteria:

  • Knowledge and practical experience of multiplex biomarker analysis, quantitative PCR, reporter cell lines and other molecular biology capabilities would be an advantage.
  • An in depth knowledge of RNA biology and interaction with the immune system.
  • An understanding of the application of immune biomarkers onto in vivo models, personal in vivo experience not essential
  • Experience of working within a toxicology laboratory environment with knowledge and experience of the drug development process
  • At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

We open this role from 22/02/2022, and welcome your application no later than 08/03/2022.

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

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