Do you have expertise in, and passion for Chemistry within Oncology? Would you like to apply your expertise to impact the rational design of the payloads linkers and conjugation technology for the next generation of ADCs? In a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. Here you’ll have the chance to define a difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and crafting the patient ecosystem. With our pipeline, the outlook is forward-thinking. Be proud to be an employee of a place that has achieved so much, yet is still moving forward. It’s time to join our global, growing enterprise as we own the way for healthcare and society.

Site description

Welcome to our Spirogen site, part of the AstraZeneca Group – Whitechapel, London… one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s significant to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you After-work events, Lunch & Learns, spacious office working environment, Networking events. Situated in the heart of London’s historical east end close to the fashionable areas of Shoreditch, Spitalfields and Brick Lane with excellent public transport links to central London.

Business area

Join us in fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our game-changing pipeline. We deliver this value through launch excellence, commercial efficiency and improving the lifecycle. By using our commercialised portfolio we are confident we can change the practice of medicine and redefine cancer treatment.

What you’ll do

AstraZeneca are seeking a highly skilled chemist for our Tumour targeted drug design and delivery chemistry group. Based in the Spirogen laboratories in London, you will be an integral member of the medicinal chemistry teams focusing on design and synthesis of drug payload molecules for novel antibody drug conjugates (ADCs). ADCs are among the fastest growing drug classes in oncology. This position offers the successful applicant the opportunity to have an impact on the rational design of the payloads linkers and conjugation.

  • Develop scientific methodology to be used in chemistry related projects, or provides technical input into the process

  • Potential to Lead team working on the rational design of the payloads linkers and conjugation technology for the next generation of ADCs.

  • Provide technical input to expand the role of ADCs beyond classical cytotoxic payloads

  • Drive the establishment and implementation of new methods, practises and ways of working by engaging others within the region and between skill groups, or use technical knowledge to provide a forward looking science and technology view and develop proposals for improved practise within drug projects across regions and areas of the business

  • Apply technical knowledge and expertise to achieve project targets in a timely fashion and to agreed quality standards.

  • Consistently up to date with trends within the external scientific world to transform novel ideas appropriately into research programs and activities within AstraZeneca

  • Share experience, knowledge and industry developments with peer scientists in AstraZeneca, or other internal concerned parties, with the purpose of growing general level of competence and industry awareness

  • Responsible for agreeing which processes and methodologies should be pursued, and making decisions about how much resources to invest in, or input into this decision making process as a valued opinion/guide

  • Supports ongoing change and risk management

  • Ensures own work, and the work of others, is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Laboratory Practice (GLP)

Essential for the role

  • Ph. D in Chemistry with Postdoc experience

  • Significant experience in a relevant scientific subject area. A mix of Medicinal and Synthetic Chemistry would be ideal

  • Theoretical knowledge and long term experience of relevant techniques and technologies

  • Understanding the process of successful drug discovery/drug development

  • Adhering to AstraZeneca business objectives that are related to R&D

  • Understanding of relevant company and national regulations and industry standards

  • Understanding of patent and IP strategies

Desirable for the role

  • Line management experience

So, what’s next?

Are you already thinking of joining AstraZeneca? Good, because we can’t wait to hear from you. Are you ready to bring new insights and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.

If you’re curious to know more please apply today!

Competitive salary package and benefits

Close Date: 11/03/2022

Where can I find out more?

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