Associate Principal Scientist, Protein Scientist

Do you have expertise in, and passion for, molecular biology, technology advancements & delivery of project milestones? Would you like to apply your expertise to impact the delivery of target proteins to support our biotherapeutics? in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!


AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.


Welcome to Granta Park Cambridge, UK, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you… Granta Park has a newly built gym with swimming pool, nursery and central food hub accessible to staff as part of the science park facilities. We also have our own bistro and deli in the AstraZeneca buildings. There are regular ‘Lunch & Learn’ events and after work socials with snacks and drinks on the last Friday of every month. This is our biggest and most spacious lab site in Cambridge…come and join us!


In the Oncology Business Unit we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease.

Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, challenging accepted norms, quick decision-making and taking smart risks. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp.

What you’ll do

We are looking for an Associate Principal Scientist to join our Biologics Engineering team based in Granta Park, Cambridge UK. Biologics Engineering is responsible for the discovery and optimisation of biologics candidate drugs across all AZ therapy areas such as oncology, respiratory and inflammation, cardiovascular, renal and metabolic diseases. We are constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for the development of in-house biologics discovery platforms and novel drug modalities to address unmet medical needs.

We are looking for someone who is recognised as an expert in the field of molecular biology, protein expression and protein purification to enable delivery of target proteins to support our biotherapeutics portfolio. In this role you will lead experiment strategies to deliver project milestones and technology advancements.

  • Leads experimental strategies in the technical areas of molecular biology, protein expression and purification to provide key proteins to enable therapeutic biologics drugs projects

  • Maintains and applies extensive expertise in molecular biology, protein expression and purification to facilitate development of next generation biologics

  • Makes detailed observations, analyses data, interprets results and devises solutions to complex scientific problems

  • Responsible for driving strategic alignment of our protein expression and purification capabilities

  • Makes decisions on project direction based on their own findings, the findings of others, and factors from outside the company

  • Provides general supervision and mentorship to other scientists and associates through matrix working and collaboration

  • Recognised as a specialist in their area of expertise. Establishes internal and external contacts and collaborations within scientific field of value to the business and presents at internal (intra- and inter-departmental) and external meetings

  • Demonstrates strong interpersonal communication by establishing good working relationships with team and department members and others within the company

Essential for the role

  • PhD with proven experience or BSc/higher degree with extensive lab-based experience

  • A deep level of knowledge and strong technical skills in molecular biology, protein expression technologies (in particular mammalian expression systems) and protein purification

  • Extensive experience in leading and troubleshooting recombinant protein delivery

  • A history of successful project delivery and publications and/or patents

  • Excellent communication, capable of developing good working relationships with individuals across organisational boundaries and experience working within a team environment

Desirable for the role

  • Background in drug discovery and development in the pharmaceutical industry

  • Experience that includes developing antibodies and next-generation biologics

  • Experience with stable cell line generation to express recombinant proteins

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  • If you’re curious to know more then please reach out to Louise Bennett

Competitive salary & benefits

Close date: 5th December 2021

Where can I find out more?

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