Do you feel passionate about the possibilities of science to change lives? Do you have a background in T cell immunology? If so, this may be the role for you.

We currently have an exciting opportunity for a highly motivated Associate Principle Scientist to drive the science and lead a team of T cell immunologists focussed on the discovery of the next generation of T cell engagers


At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.

Business Area

AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas – breast, ovarian, lung and haematological cancers.

What you’ll do

We are seeking a highly motivated Associate Principal Scientist in the T cell immune engagers team with deep scientific and technical expertise in TCR signalling, T cell biology and a track record of successful scientific leadership to join our team in Cambridge, UK. As an experienced Project Lead within the Immuno-oncology (IO) Bioscience team, you will play a pivotal role in identifying the next generation of innovative IO therapies, and in deepening our understanding of cancer immunology.

Main Duties and Responsibilities

The position will be focused on early discovery efforts within the Circuits & Engagers Team with a focus on exploring costimulation into different T cell engaging approaches. Working in this scientific leadership role you will apply your technical and scientific experience to discover innovative therapeutic approaches. As the bioscience lead on cross-functional project teams you will be responsible for developing and delivering the preclinical strategy to advance projects through the drug discovery pipeline.

You will stay up to date with the latest discoveries in T cell immunology and tumour immunology, share your expertise both within and beyond the bioscience group, publish peer reviewed articles on your research and develop, and lead, external collaborations. You will matrix manage the project bioscience team, providing expert advice and mentorship, interpreting complex data and making high level recommendations. You will apply your influencing, coaching and mentoring skills to ensure effective cross-functional working within teams. You may also directly line manage bioscience team members, helping to set goals and objectives and coordinating their professional development.

Essential Requirements

  • PhD (or equivalent) in a biological science with at 5-10+ years of research experience post-PhD in academia or industry. Industry experience is preferred but not essential.

  • Deep expertise in immune-oncology particularly around T cell receptor biology, T cell signaling, costimulation and immune synapses, plus broad understanding and enthusiasm for translating basic science into novel cancer therapies

  • Line management experience

  • General knowledge of biologics drug development

  • Track record of successful scientific leadership (e.g. grants, patents, publications, experience leading projects through milestone transitions in industry/biotec)

  • Technical expertise in preclinical model systems that can be applied to cancer immunology research

  • Excellent scientific communication skills including both written reports (e.g. manuscripts) and oral presentations to broad and diverse audiences

Desirable Requirements

  • Experience working in the field of IO drug discovery

  • Experience working with successful cross-functional scientific project teams

  • Authorship of patents, grants and/or publications in top-tier scientific journals

Locations: Cambridge UK

Salary: Competitive + Excellent Benefits

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.
  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.
  • If you’re curious to know more then please reach out to sophie Halpin.We welcome your application, no later 18h March 2022

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