Director AI Science is responsible for defining AI science strategy and/or managing teams applying sophisticated quantitative expertise in advanced mathematical disciplines to develop innovative data science solutions that generate
business and scientific insights across a portfolio of projects. The role will develop innovative strategies and/or lead groups which utilise foundational and cutting-edge techniques, in combination with business domain knowledge, to generate impactful business and scientific insights. The role will be responsible for influencing senior internal stakeholders and manage external collaborations and vendors to deliver effective solutions. The role may sit on the functional Leadership Team and influence functional strategy.

Clinical Pharmacologist, Clinical Pharmacology and Quantitative Pharmacology (CPQP) in Vaccine & Immune Therapies , Neuroscience, & Clinical Immunogenicity

Cambridge UK, Gaithersburg US

Salary & Benefits Competitive

Diverse Minds. Bold Disruptors. Meaningful Impact.

AstraZeneca is a global, innovation-driven BioPharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious disease. But we’re more than one of the world’s leading pharmaceutical companies.

We are harnessing digital, data science & AI to help us achieve the next wave of breakthroughs – to do things that have never been done before. It’s a place to think differently – to find new ways of handling and treating diseases. We are trusted and empowered to explore.

What you’ll do

  • Accountable for expert data integration, analysis, interpretation, and reporting of clinical pharmacology results at the study level to support project (project team/governance)
  • Jointly accountable with the pharmacometrician for providing a scientific justification for the dose selection/justification
  • Jointly accountable with the bioanalytical lead for selecting appropriate analytical large PK, biomarker and ADA assays
  • Participation in and accountability for peer review of ongoing activities, reports and presentations
  • Contribute to regulatory documents and interactions (written and oral)
  • Presentation of Clin Pharm results to internal and external forums
  • Contribute to internal initiatives to develop the clinical pharmacology team including its processes
  • Compliance with Good Clinical Practice (GCP) regulations as well as internal/external guidance’s

Essential criteria

  • Late stage clinical development experience
  • Large molecule experience
  • Significant regulatory experience (written)
  • Expert knowledge of pharmacokinetics and Model-Informed Drug Development (MIDD)
  • Good knowledge in pharmacology, drug targets and core disease areas
  • Proven broad translational development expertise and experience
  • Demonstrated ability to identify, develop and implement clinical pharmacology activities at a project level
  • Good verbal and written communication skills
  • Good knowledge of global regulatory, compliance, processes, standards and issues specific to clinical pharmacology
  • PhD degree with relevant experience required
  • Training and experience with PK software (Phoenix, WinNonlin)
  • M&S expertise with experience using relevant software and tools within the field of MIDD (e.g. SIMCYP, R, NONMEM, Monolix)

Desirable criteria

  • Bioanalytical experience
  • Biomarker strategy experience
  • Translational science experience
  • International scientific reputation gained from scientific publishing in the field of DMPK/Clinical Pharmacology

Why AstraZeneca

Be empowered to be innovative and creative where difference is valued

So, what’s next?

Complete your application before the below closing date.

This role is open from 23/02/2022 and we welcome with your application no later than 23/03/2022

Where can I find out more?

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