This is a scientific job with responsibility for translational modelling, population PK, PKPD, exposure-response, disease modelling, and simulations in all clinical development phases. With support from the senior pharmacometricians/clinical pharmacologists and the TA lead, the incumbent will be responsible for integrating and analysing internal (and external) data to support interpretation and decision making. Also support clinical pharmacology development program to provide differentiated medicine and the right dose to patients.

Clinical Pharmacometrician/Clinical Pharmacologist, Early Clinical Development

Cambridge UK, Gaithersburg, USA

Salary & Benefits Competitive

Make a more meaningful impact to patients’ lives around the globe

Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

With colleagues from 70 countries across our UK sites, you’ll find your voice in an inclusive and diverse community. Our Cambridge hub is high on the target list of international destinations to work and stacked with globally important roles.

We’re investing to enhance our understanding of disease as we work towards creating the next generation of therapeutics and pioneering new approaches to better predict clinical success.

This is a scientific job with responsibility for translational modelling, population PK, PKPD, exposure-response, disease modelling, and simulations in all clinical development phases. With support from the senior pharmacometricians/clinical pharmacologists and the TA lead, the incumbent will be responsible for integrating and analysing internal (and external) data to support interpretation and decision making. Also support clinical pharmacology development program to provide differentiated medicine and the right dose to patients.

What you’ll do

  • Accountable for data integration, analysis, and reporting of M&S/ Clinical Pharmacology results at the study level

  • Accountable for developing and maintaining data analytics apps such as immunogenicity and Shiny dashboard to aid project discussions with clinicians

  • Accountable for executing state-of-the-art M&S techniques with direct value for the project

  • Contribute M&S activities to influence clinical pharmacology study designs and go/no go decisions

  • Development of (mechanistic) drug-disease models to support projects within a specific disease domain

  • Contribute to regulatory documents and interactions (written)

  • Presentation of M&S/ Clin Pharm results in internal and external forum

  • Contribute to internal initiatives to develop the pharmacometric discipline including its processes

  • Participation in peer review of ongoing activities, reports and presentations

  • Compliance with Good Clinical Practice (GCP) regulations as well as internal/external guidance’s

Essential Criteria

  • Demonstrated experiences in pharmacometrics, including PK, PKPD and/or statistics

  • Strong quantitative skills (e.g. experience in population modelling, understanding of immunogenicity, statistics, systems and translational pharmacology modelling).

  • Ability to execute clinical Pharmacometric activities at a study and project level

  • Basic oral and written communication skills

  • PhD degree in pharmacometrics or clinical pharmacology or DMPK M&S (fresh PhD or Post-docs are encouraged to apply). Or M.Sc./Pharm.D with relevant experience required

  • Training and experience with PK software e.g. NonMem, R, Monolix, Simcyp

Desirable Criteria

  • Scientific publishing in the field on pharmacometrics/Clinical Pharmacology

  • Early or late phase clinical development experience/awareness

Why AstraZeneca

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date.

This role is open from (9th March 2022) and welcome with your application no later than (23rd March 2022)

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

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