Cryo-EM Scientist Vacancies (Ref: CE/0721)

Job Type: 2 year fixed term contracts, multiple roles

Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery (FBDD) platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to two launched oncology drugs (Kisqali® partnered with Novartis and BalversaTM partnered with Janssen). Astex continues to grow and focuses on Oncology and Neurological Disorders.

Historically Astex’s fragment screening platform has relied upon X-ray crystallography to support structure-based drug discovery (SBDD) and Astex has comprehensive in-house X-ray crystallography facilities. However, the increased ability of cryo-EM to deliver atomic resolution structures has led to Astex establishing a state of the art, in-house, cryo-EM facility. This facility includes two Glacios and one Krios transmission electron microscopes (TEMs), a fully equipped cryo-EM sample preparation laboratory and extensive computing infrastructure. Astex has also developed custom data collection and processing workflows to facilitate the rapid generation and interpretation of cryo-EM structures for SBDD and FBDD.

Astex’s Molecular Sciences group currently has multiple, fixed term contract, opportunities available for scientists working in cryo-EM. We are seeking highly driven scientists who are keen to help develop Astex’s cryo-EM capabilities and Astex’s general FBDD/SBDD platform. The positions are all based in Cambridge, UK.

Candidates should have a PhD and demonstrable skills and experience in one, or more, of the following areas:

  • Generation, optimisation and analysis of negative stain and cryo-EM grids
  • Processing of single particle cryo-EM data and familiarity with cryo-EM software packages
  • Performing single particle cryo-EM on a range of targets
  • Expression, purification and characterisation of proteins, ideally including membrane proteins and/or protein complexes

Candidates should also have:

  • Excellent communication skills, creativity and self-motivation
  • The ability to work independently, or as part of a multi-disciplinary teams

Practical experience of using other biophysical methods to characterise proteins and protein-ligand interactions is desirable, but not essential.

We offer excellent training and career development opportunities as well as competitive salary and benefits package.

To apply you will need to submit the following documents:

  • Your CV
  • A Covering Letter detailing your suitability for the role and motivation for joining Astex

Please send your application, quoting the reference number CE/0721 to

At Astex we embrace diversity and equality of opportunity. We are committed to building an inclusive and diverse company representing all backgrounds, harnessing industry-leading scientific innovation and behaviours

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