Functional Genomics Scientists – All levels

We have a range of vacancies at career grades Research Scientist, Senior Research Scientist and Associate Principal Scientist.

Functional Genomics Scientists (Phenotypic Screening) – All levels

Location: Granta Park, Cambridge, UK

Competitive salary and benefits

AstraZeneca is a science-led, global biopharmaceutical company, committed to improving the health and lives of people across the globe through our research and development platform and a growing late-stage pipeline.

We have a range of vacancies at career grades Research Scientist, Senior Research Scientist and Associate Principal Scientist, that would reflect the level of candidate experience. This would be determined at the start of the interview process.

Within Discovery Scientists we are growing our capabilities in Functional Genomics, a group responsible for the identification and validation of novel targets to support AstraZeneca’s clinical pipeline.

Whichever role you’re successful in, you’ll be joining an extraordinary team with a track record of delivering portfolio impact.

What’ll you do?

Working closely with therapy area leads, we onboard disease relevant models to provide at-scale screening capabilities utilising CRISPR/Cas, small molecule and protein libraries. We believe that by embedding cutting edge functional genomics and better modelling disease complexity in our validation cascades, we can reduce the attrition of targets as they move through the drug discovery process.

These are laboratory-based roles, where you will craft, lead and resource experiments. You will be comfortable working as part of a cross functional team to interpret data and determine next steps to drive projects forwards. You will present data to key stakeholders internally and achieve external scientific transparency through oral presentations and peer-reviewed publications.

We are looking for candidates with an interest in target discovery as well as proven expertise in screening or flow based immune cell assays. If you have a passion for drug discovery and science, then this is an excellent opportunity to contribute as we build a world leading functional genomics discovery platform.


  • Ph.D in Cell Biology, Immunology or a related subject area with 1-5+ years’ experience in a research setting preferably in the pharmaceutical or biotechnology industry
  • Expertise and experience in one/both of the following areas
    • Building and developing multiparametric assays in primary immune cells such as T cells, B cells or myeloid cells (e.g. flow panels for surface markers, cytokines, co-culture assays) – ideally coupled to the use of CRISPR to interrogate gene function
    • Building and developing arrayed phenotypic or genetic perturbation screens such as siRNA or CRISPR, for target identification and validation – ideally at 384 well scale and with the use of liquid handling and automation
  • Ability to deliver in a fast pace environment, adapt to changing priorities and be a valued member of a high performing team
  • Capable of scouting for scientific and technical developments in the fields of CRISPR screening, genome engineering and functional genomics
  • Excellent team working, communication and networking skills with experience of interacting optimally across interfaces of subject area, culture, and expertise


  • Background in immunology, immuno-oncology or autoimmunity

*** We will be reviewing applications and shortlisting on a rolling basis – as such we reserve the right to withdraw this vacancy ahead of the stated closing date ***

AZ Cambridge

Currently based at our Darwin building on the Cambridge Science Park, the Functional Genomics team are excited for their pending relocation to our brand new, state-of-the-art R&D facility, which was officially un-veiled in November 2021, by His Royal Highness, The Prince of Wales.

The Discovery Centre (DISC), located at the heart of the Cambridge Biomedical Campus, is designed to play a central role in our mission to deliver life-changing medicines to patients. As our largest research and development centre in the UK, it will have more than 2,000 people working across therapy areas and drug discovery and development once fully occupied.

So, what’s next?

Please complete your application before the below closing date. If you know someone who would be a great fit, please share this posting with them.

This advert will be running from Friday, 25th February 2022 and we welcome your application as soon as possible. The scheduled closing date is Sunday, 20th March 2022.

Where can I find out more?

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