Head Of Oncology Safety, Clinical Pharmacology Safety Sciences


Cambridge, UK; Gaithersburg, US; Boston, US

Meaningful Impact. Make a more meaningful contribution Impact patients’ lives every day

Make a more meaningful impact in your career, with greater ownership and accountability to make a contribution. And in return… we’re looking for people driven by making a difference to patients and society, dedicated to doing the right thing.

What we do

Ultimately, our aim is to work towards a cure for some of the world’s most complex diseases. Whether that’s by shaping the patient ecosystem and focusing on outcomes, or by progressing potential medicines and accelerating their launch.

Why we love it

Join the team that follows the science unlike anywhere else. This is the place for curious minds. Dig deep into the biology of complex disease and uncover breakthroughs. With our ground-breaking pipeline comes a bright future – a secure job, exciting opportunities and varied work. We’re on an exciting journey to pioneer the future of healthcare!

The role

As the global head, executive director Oncology Safety in the Safety Sciences department of Clinical Pharmacology and Safety Sciences (CPSS) you will be responsible and accountable for all aspects of Oncology R&D portfolio safety from target selection through clinical development, submission, launch and life-cycle management. Playing a key part in bringing innovative life-changing oncology medicines to patients based on a deep understanding the non-clinical safety requirements to support oncology drug discovery, development and registration.

What you’ll do

Strategy & Leadership

  • inspire scientific leadership and set a leading strategy for Oncology Safety – specifically ensuring the “right safety” of Immuno-oncology agents, mAbs, cell therapies, antibody-drug conjugates, PROTACs and small molecules spanning mechanisms such as tumour drivers and resistance mechanisms, DNA damage response and epigenetics
  • will deliver the “Right Safety” profile for Oncology portfolio priorities for Oncology disease indications (from target/concept validation to candidate delivery) and provide insight and judgement to enable the successful delivery of innovative, life changing medicines
  • Accountable for all non-clinical safety aspects across the Oncology portfolio supporting all phases of clinical development including all marketing submissions and support of Life Cycle Management (LCM)
  • Manage individual performance as well as significant budget and resources


  • Continuously develop novel safety science in the predictive safety/toxicology and drug discovery arena and as such contribute to the internal global innovative safety strategy as well as shaping the safety and toxicology science field externally.
  • Identify internal and external industry trends, and anticipate future changes that impact the success of non-clinical safety support to the oncology portfolio.
  • Advance AstraZeneca’s safety science through balancing unique, groundbreaking capabilities, application of data science and AI.


  • Support and collaborate with the Head of Safety Sciences in scientific and managerial responsibilities
  • Take accountability and drive success beyond Oncology Safety, influencing other CPSS and AZ functional partners to drive alignment with and support for non-clinical safety strategies.
  • engage with internal and external partners, academic groups, regulators and external experts, this individual will identify internal and external industry trends and anticipate future changes that impact on oncology safety science/business support promoting courageous leadership, innovation and collaboration.
  • Promote inclusion and diversity agendas to build successful teams within and across departments, supporting talent development and create a great place work.

This individual will report to the VP, Safety Sciences and be a member of the global Safety Sciences leadership team, contributing to strategic, scientific and operational aspects of Safety Science. In addition, they will be a member of the Early Oncology Research Board influencing project governance and the disease area strategy.

Essential qualifications and experience:

  • PhD (Toxicology, Pharmacology, Biology or, Pathology), DVM or MD with ~10-15 years of experience
  • Strong leadership skills and line management experience with a positive team engaging attitude and a track record in the leadership, management and talent development of individuals and teams
  • Track record of leading impact on drug R&D within pharmaceutical industry with a strong focus on safety assessment
  • Experience of research and project impact relevant to oncology spanning small molecule, large molecule and biologic therapeutics.
  • Leader of collaborations with academia, biotech and/ or pharma industry.
  • Demonstrated project safety impact from target selection through clinical development
  • Track record of scientific innovation: leading cutting-edge, and new to the industry science
  • Leadership experience in non-clinical safety vs oncology drug discovery and development from the pharmaceutical industry or biotech sector.


  • A strong track record of publishing in high impact journals
  • Experience of leading external collaborations and external partnerships
  • Comfort with financial and scientific/technical information
  • An excellent understanding of AstraZeneca, its strategy, business, products and Research and Development pipeline

Why AstraZeneca

At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

Salary: Competitive

So, what’s next?

Are you already imagining yourself joining us? Good, because we can’t wait to hear from you!

Advertising opens on 30th November 2021 and we welcome with your application; CV and cover letter, no later than 15th December 2021

For more information please contact: caroline.neve@astrazeneca.com

Additional information

Our Company Values & Behaviors underpin everything we do so please take a moment to familiarize yourself with them. You may also want to check out our new R&D Video showing how we turn Science into Medicines. Covid-19 Resources

More information about our sites:

  • Cambridge, UK
  • Gothenburg, Sweden
  • Gaithersburg, US

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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