Immunotoxicology Associate Principal Scientist

Bring out the best in each other, and yourself, by working together as one

Be appreciated for your contributions. Our culture of recognition and reward means each of us feels supported and empowered to step up and take responsibility. With all the tools you need to excel at every level, coupled with ongoing constructive feedback and coaching, there’s no better place to bring out your best.

What we do

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide.

How we do it

The shared creativity through both internal and external collaboration unlocks challenges and brings new solutions!

The role

Functional and Mechanistic Safety is a global department sited within Clinical Pharmacology and Safety Sciences (CPSS) function where application of innovative science drives the design, selection and development of safer medicines.

The department works collaboratively with other departments within CPSS on novel drug programmes from early discovery through to clinical development. We work with a wide range of drug modalities targeting a number of disease indications. An exciting opportunity now exists to join our Immunotoxicology Group to help drive the development of safe and innovative oligonucleotide therapies to improve patients’ lives.

The Immunotoxicology team uses cutting edge platforms and in vitro/ex vivo models to develop bespoke solutions to address potential immune safety questions across a wide portfolio. In this key role, you will apply your existing immunology problem-solving expertise alongside that of the collective team to develop innovative strategies to understand and mitigate unwanted immune-mediated adverse reactions to oligonucleotide drug candidates. This will include investigation of immunological pathways and molecules to afford mechanistic understanding across multiple organs, working closely with safety scientists in other areas of expertise to fully understand the safety profile.

You should be able to search-out and apply multiple strands of knowledge into coherent strategies and bespoke investigations to assess the interaction of ASOs with the immune system. This will involve initiating collaborations with academic teams externally to access the leading scientific knowledge in the field.

You should be highly motivated, innovative, detail-oriented, creative, well organised and able to work independently when designing and executing experiments and will be expected to lead and prioritise multiple projects and tasks in line with the objectives of the Immunotoxicology and oligonucleotide project teams. You will be responsible for providing expert advice on the immunotox strategy for the immune safety of oligonucleotides to safety representatives on project teams and leading problem-solving activities using in vitro and ex vivo models.

This role will involve close interactions with many other AZ scientists and collaborators in a highly international environment. You will be expected to continuously develop your immunotoxicology expertise and scientific network, regularly presenting our innovative science through peer-reviewed publications and presentations at selected scientific conferences. This will enable you to influence our Immunotoxicology safety strategy, develop our technical problem-solving capabilities, and contribute to our external scientific reputation.

Essential requirements

  • Bachelors degree or equivalent qualification in an appropriate subject area (immunology, cell biology, molecular biology etc)
  • A PhD in an immunology field or equivalent industrial experience in the field of immunology.
  • Knowledge and practical experience in the field of immunology/immunotoxicology and an understanding of the potential adverse outcomes of immune modulation, experience within the nucleic acid field an advantage.
  • In depth theoretical understanding and practical experience of in vitro and ex vivo cell-based assays systems utilising immortalised cell lines and primary tissues.
  • Experience in leading hypothesis-led strategic investigation
  • Extensive experience in collation, interpretation and communication of complex data
  • Ability to work both independently and within a team environment, supporting colleagues and open to support in return as required.
  • Confidence in communicating findings globally both internally and externally through oral and written forms in a clear and precise manner.
  • Strong scientific leadership, evidenced by a recent publication track record or evidence of the ability to independently lead the drafting and review of publication manuscripts
  • Excellent interpersonal skills
  • Willingness to challenge conventional thinking and implement creative ideas balanced with a high regard and understanding for the regulatory framework in which AstraZeneca operates is expected
  • Ability to follow Good Laboratory Science standards, Safety, Health and Environment standards and other relevant external regulation.

Desirable requirements

  • An understanding of in vivo models, personal in vivo experience not essential
  • Knowledge and practical experience of flow cytometry and multiplex analysis would be an advantage.
  • Experience of working within a toxicology laboratory environment with knowledge and experience of the drug development process
  • An understanding of immunotoxicolgy and/or toxicology biomarker application in vivo.

Salary: Competitive

So, what’s next?

Are you already imagining yourself joining us? Good, because we can’t wait to hear from you!

Advertising opens on 31st April 2021 and we welcome with your application; CV and cover letter, no later than 31st May 2021

For more information please contact: alexander.doyle@astrazeneca.com

Additional information

Our Company Values & Behaviors underpin everything we do so please take a moment to familiarize yourself with them. You may also want to check out our new R&D Video showing how we turn Science into Medicines. Covid-19 Resources

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