Department of Life Sciences, Faculty of Natural Sciences
Salary: £33,977 – £38,360 per annum
Location: South Kensington Campus
Interested in the cancer microenvironment and/or metabolism? If so, this job is perfect for you! This is an exciting opportunity to be part of a project investigating microenvironment-mediated treatment resistance in leukaemia, with the ultimate aim of bringing novel approaches to treatment to the clinic. As a Leukaemia Research Technician, you will work closely with a clinician-scientist (Dr Richard Burt) on a 5-year CRUK-funded project investigating mechanisms behind treatment resistance in acute lymphoblastic leukaemia in adults and children.
You will join the research group headed by Dr. Lo Celso which focuses on haematopoiesis, cancer and in vivo imaging. In addition, the Lo Celso group has strong interactions with both the Imperial College Centre for Haematology (Hammersmith Campus) and the Francis Crick Institute. You will work at South Kensington and the Francis Crick Institute, and there especially in collaboration with Dr Mariia Yuneva’s group and the Metabolomics Platform, a world-class biomedical research institute in central London.
The work has strong translational potential with the aim of identifying novel therapeutics and treatment strategies to overcome treatment resistance in acute lymphoblastic leukaemia in the clinic.
You will be supported to register for a PhD degree.
Duties and responsibilities
The project will involve using intravital microscopy and metabolomics in murine and xenotransplantation leukaemia models to characterise both the structural position of the treatment resistant leukaemia cells within the bone marrow and their metabolic perturbations compared to the bulk, treatment sensitive population of leukaemia cells. Your work will involve experiments using standard techniques of cell and molecular biology, microscopy and stable isotope labelling metabolomics.
- BSc in relevant subject or equivalent (or extensive previous laboratory experience)
- At least six months research experience in the cell biology field
- Experience in cell and molecular biology techniques and microscopy
- Track record of contribution to successful academic research
- Proven ability to learn and apply new techniques and concepts is necessary
- Excellent organisational skills, attention to detail and record keeping
The position is full-time and fixed term up to 31 August 2026. You will be based at South Kensington Campus, with travel to the Francis Crick Institute as required.
Should you require any further details on the project and the role, please contact Dr Richard Burt (firstname.lastname@example.org).
The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/
The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/
Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.
Closing date: 30/11/2021
To apply, visit www.imperial.ac.uk/jobs and search by the job reference NAT01017.