Postdoc Fellow – Exploring genetic resilience using 500K exomes

Postdoc Fellow – Exploring genetic resilience using 500,000 exomes and genomes

Cambridge, UK

Competitive Salary on Offer

Interested in contributing to genomics research? Here’s your chance!

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. We’re proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives – and are made to feel valued, energised and rewarded for their ideas and creativity.

Our Centre for Genomics Research (CGR) has an exciting opportunity for a Postdoc Fellow to contribute to its Genomic Initiative. The Genomic Initiative includes the sequencing of participants from AstraZeneca clinical studies as well as analysing the sequence data from large population cohorts, including the 500,000 UK Biobank participants.

About the Opportunity:

This role is an opportunity to be part of ground-breaking research at the forefront of human genomics using whole exome and whole genome sequencing data from the world-renowned UK Biobank to explore genetic drivers of disease resilience. People with strong genetic or environmental risk factors who remain healthy are disease resilient. This can be driven by genetic variants, and the genes that harbour those variants can represent promising candidate drug targets. Advanced access to whole genome sequencing data will allow structural variants and non-coding variants to be studied in addition to single nucleotide variants and indels. Phenotypic data includes hospital records, self-reported conditions, blood-based biomarkers, Olink proteomic data, and more.

Working alongside our CGR Analytics & Informatics team, and as part of our global Postdoc Fellows community, you’ll have the opportunity to collaborate with world leading specialists, both within and outside of AstraZeneca. Your research will lead to high quality peer-reviewed publications and opportunities to present at national and international meetings.

Don’t miss out on this vital research project! We’d love to have you join the team.

Education and Experience:

Essential:

  • A Doctoral degree in human genomics, statistical genetics, bioinformatics, computational biology or related field
  • Expertise analysing human exome or genome sequencing data
  • Coding skills for genomic analysis (e.g. R, Perl, Python, UNIX, Bash, Slurm, high performance computing)
  • Understanding or interest in the potential of genomics to impact drug discovery
  • Highly motivated, well organised and inventive

Desirable:

  • Experience analysing and interpreting health data
  • Experience quantifying and interpreting the clinical relevance of rare variants
  • Experience in case-control sequencing based statistical analyses
  • Experience in applied statistics and/or machine learning
  • First-authored publications in leading scientific journals

About our Postdoc Programme

Our Postdoc Programme is for self-motivated individuals looking to tackle interesting, high impact projects in a collaborative, challenging environment.

Working with colleagues from diverse backgrounds, together with a world class academic mentor aligned specifically to your project, you’ll be empowered and supported to drive the success of your project, publish papers, and achieve your goals. Networking within your field and the scientific community to build connections and gain exposure for your publications.

You’ll also benefit from our Postdoc Programme training.

Initial Postdoc Programme job offers are on a 2 year, Fixed Term Contract basis, with a 1 year, merit-based contract extension.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

Advert opening date – July 20, 2021

Advert closing date – August 22, 2021

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