Research Associate in Structural Biology of Bacterial ESCRT-III-like Systems

Job summary

We are seeking to recruit an enthusiastic and motivated structural biologist to join the group of Dr Harry Low, Department of Infectious Disease (www.thelowlab.org). The research project focuses on determining the role and mechanism of ESCRT-III-like membrane remodelling proteins in bacteria. Methodology will include cryo-electron microscopy (EM) single particle and tomography studies, light microscopy and a suite of biophysical, biochemical and cellular assays to determine structure and function. The position is funded by the BBSRC.

Duties and responsibilities

  • To take responsibility for the day-to-day running of biochemical/structural biology research on ESCRT-III-like membrane remodelling proteins.
  • To carry out the design and execution of appropriate experiments based on high-level research goals.
  • To contribute to regular laboratory meetings and deliver presentations at internal and external seminars.
  • To produce accurate report-ready data and to assist in the preparation of written progress reports and publications as required.
  • To be proficient in new approaches and techniques and integrate these approaches into your research projects.
  • To take initiative in the planning and execution of research, and in the development of collaborations with other groups at Imperial, and external collaborators.

Essential requirements

  • Research Associate: Hold a PhD in Cryo Electron Microscopy (single particle or tomography) or a closely related discipline or equivalent research, industrial or commercial experience
  • Research Assistant: Near completion of a PhD (or equivalent) in in Cryo Electron Microscopy (single particle or tomography) or a closely related discipline or equivalent research, industrial or commercial experience
  • Strong research track record in structural biology including cryo electron microscopy, X-ray crystallography or NMR
  • Experience in the design and execution of workflow for structure determination of proteins, from molecular biology/biochemical experiments (e.g. DNA cloning and mutagenesis, protein purification) to electron microscopy data collection, processing and model building
  • At least one first author publication in an international journal

Further information

This is a Full Time and Open-ended contracts based at the South Kensington Campus.

Should you require any further details on the role please contact: Harry Low directly at

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see: https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/

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