Scientist, Next Gen Antibody Discovery, Biologics Engineering

Do you have expertise in, and passion for therpaeutic antibody discovery using cutting edge single B-cell technologies? Would you like to apply your expertise to impact the next generation biotherapeutics portfolio in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

About AstraZeneca

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Site description

Welcome to Granta Park, Cambridge (UK), one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…Cambridge is one of the most exciting bioscience hotspots in the world and plays a central role in our mission to deliver life-changing medicines to patients. Granta Park has a gym, nursery and central restaurant/coffee place as part of the science park facilities that are accessible to our staff. We also have our own bistro and deli in the AZ buildings. There are regular lunch & learn events including running clubs and after work socials on the last Friday of every month. This is our biggest and most spacious lab site with easy access from all major routes and ample car parking available – come and join us! Please be aware that towards the end of 2022 you will be required to move the our new state of the art Cambridge Biomedical Centre.

Business area

In the Oncology Business Unit we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease. Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, challenging accepted norms, quick decision-making and taking smart risks. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp.

What you’ll do

We are seeking a highly motivated Scientist to help develop and implement our next-generation B cell discovery platforms in their application to pre-clinical programs. The successful candidate will add to our team of multidisciplinary and passionate scientists excited by research at the interface between technology and Biology. You will be a well-organised and a highly productive bench scientist that can design and execute experiments efficiently, as well as analyse, interpret and present data. The role entails the isolation of antigen specific B-cells by fluorescent activated cell sorting, rescue and sequence of antibody genes by next generation sequencing enabling the identification of next generation therapeutics for drug discovery programs.

Essential for the role

  • A BSc with laboratory experience in flow cytometry, molecular biology, screening and sequencing

  • Track record of routine flow cytometry analysis of primary cells using multicolour/multiparameter sorting.

  • Track record of general molecular biology skills & techniques (e.g. RT-PCR, Cloning (restriction enzyme and/or assembly methodologies), Sanger sequencing/analysis)

Desirable for the role

  • Hands on fluorescent activated cell sorting experience

  • Hands on experience with Flow cytometer/FACS machine maintenance

  • Experience of single and bulk antigen specific B-cell sorting & population analysis

  • Experience of single cell RT-PCR, NGS library generation, sequencing & analysis (e.g. using 10X Genomics platform)

  • Basic biochemical screening assay skills e.g. ELISA, cell based binding assays (e.g. Mirrorball, ELISA, etc.), HTRF binding assay

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  • If you’re curious to know more then please reach out to Louise Bennett

Competitive salary package and benefits

Close Date: 14/03/2022

Where can I find out more?

Our Social Media,

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

“As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results – pymetrics will not be used solely in our decision-making process but will help us gather additional insight.”

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