Scientist, Oncology Bioscience

This is an exciting opportunity to join the Oncology Bioscience group in London as a laboratory based scientist. You will become part of a large team of bioscientists and play a pivotal role in the delivery of robust and high quality ex vivo data to support drug discovery projects within the Oncology portfolio. Working collaboratively with other disciplines across AstraZeneca you will have the opportunity to contribute to biomarker discovery and development for early and clinical phase projects. You should have a background in Oncology or a related field and a strong passion for experimental work and delivering data from the laboratory. You will use your scientific judgement, ability to analyse data, lab experience and communication skills to contribute to experimental design and interpretation for either early or late stage drug discovery programmes. As a Scientist within Bioscience, you’ll have a good understanding of the range of procedures relating to bioanalysis/bioscience. You will expertly design and conducts laboratory projects/experiments, develop methods, generate interpret and report scientific data. You’ll also be proficient in trouble shooting and theory.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

Site description

Welcome to our Spirogen site, part of the AstraZeneca Group – Whitechapel, London… one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you After-work events, Lunch & Learns, Bright and spacious sustainable office working environment, Networking events. Situated in the heart of London’s historical east end close to the vibrant and fashionable areas of Shoreditch, Spitalfields and Brick Lane with excellent public transport links to central London.

Business area

In the Oncology Business Unit we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease.

Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, challenging accepted norms, quick decision-making and taking smart risks. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp.

What you’ll do

  • Executes routine drug discovery research experiments independently by applying the techniques of Bioconjugation of small molecules to antibodies and related scaffolds

  • Perform cell based in vitro assays involving small molecules and bioconjugates

  • Works independently within a team and collaboratively with internal and external stakeholders to ensure the efficient relay of information

  • Maintains a well-developed understanding of approaches to Bioconjugation techniques and cell based bioassays, applying a broader functional knowledge to support the team

  • Communicates results to team members and is involved in the interpretation of data with little or no guidance in a clear and concise manner, with a clear understanding of its implications within drug discovery

  • Regularly shares relevant external published papers with peers

  • Ensures own work, and work of peers, follows Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Essential for the role

  • Ph.D and/ or M.Sc in Chemistry, Biochemistry, Chemical engineering or relevant discipline

  • B.Sc in above disciplines with relevant industrial experience

  • Deep Understanding of chemistry and protein biochemistry

  • Hands-on experience in a chemical/biochemical/bioassay laboratory

  • Experience with GE AKTA system, Unicorn chromatography software

  • Experience in working with cell culture/sterile techniques and GraphPad Prism

  • Experience of protein/bioconjugate analysis, characterisation and quantitation by UV/Vis spectroscopy, size-exclusion/hydrophobic interaction/ion exchange chromatography, HPLC and LCMS

  • A track-record of protein modification/purification experience

  • Antibody-drug conjugates experience might be beneficial

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  • If you’re curious to know more then please reach out to Louise Bennett

Competitive salary package and benefits

Close Date: 11/10/2021

“As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results – pymetrics will not be used solely in our decision-making process but will help us gather additional insight.”

Where can I find out more?

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