Senior Data Scientist / Associate Director in Bioinformatics

The Informatics Specialist will apply scientific domain-specific knowledge (in chemo, bioinformatics) and/or clinical disease area expertise, specialized data processing techniques, analytical and machine learning capabilities to extract scientific insight and hypotheses from data. The role will work in partnership with scientists and clinicians to support the generation of innovative solutions, within defined project scope and aligned to established frameworks, which support decision-making in pre-clinical, development and post-market activities.

Senior Data Scientist / Associate Director in Bioinformatics

Cambridge, UK or Gothenburg, Sweden

Competitive Salary & Benefits

Be empowered to be innovative and creative where difference is valued. Join a place built on innovation and creativity. Where different views and perspectives are welcomed and valued. An environment that champions inclusion, and teams that reflect the diversity of the communities that we serve.­

Follow the science to explore and innovate. Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world’s most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world.

To ensure that we can go after any molecular target with a therapeutic promise, AstraZeneca has invested in establishing a variety of therapeutic modalities that act via different mechanisms of action.

What you’ll do

We are now seeking an innovative Bioinformatics researcher with strong desire to be a key contributor for establishing and developing safe RNA therapeutics such as novel amplifying RNAs, while learning new frontiers in RNA therapeutics and computational biology. You will join us in the Imaging, AI & Data Analytics, within the Clinical pharmacology and Safety Sciences (CPSS) unit at AstraZeneca.

You will partner with CPSS scientists and interact across the R&D therapeutic area units spanning multiple strategic global locations (US, UK, Sweden) for enabling safe and efficacious therapeutic RNA-based molecules in multiple disease areas. You will use computational approaches to generate biological insights, enable new computational capabilities, and will be key in driving the computational efforts in establishing and developing novel, and innovative RNA-based therapeutics.

The position is a rare opportunity to gain experience in a variety of computational approaches relating to RNA therapeutics and work with industry leaders, while publishing and contributing directly to the development of future drugs across many diseases.

Responsibilities

  • Drive hypothesis generation by applying computational biology approaches, data integration, and biological knowledge
  • Build and/or Implement new computational biology capabilities to translate biological data into insights.
  • Be responsible for pioneering and implementing novel off-target analysis and mechanistic analysis platforms
  • Publish in peer-reviewed journals
  • Help educate and train AstraZeneca colleagues in computational biology and related areas
  • Identify and proactively help build strategic directions in computational biology

Essential Requirements

  • A Doctoral degree in computational biology or related field (e.g., Biological science, Computer science), preferably with postdoctoral or equivalent experience in RNA biology
  • Demonstrated experience in multiple areas in at least three of the following fields of bioinformatics: DNA/RNA-Seq, gene expression analysis, GWAS, systems biology, and gene pathways/networks
  • Demonstrated expertise in R, Python, or Perl
  • Demonstrated experience in the use of many bioinformatics tools relating to genomic (DNA/RNA) sequence analysis
  • Strong understanding of computational biology tools and databases.
  • A keen demonstrated interest in learning data science techniques for biological problems

Desirable requirements

  • Hands-on experience in data analysis of therapeutic oligonucleotides (e.g., small RNA analogs, amplifying RNAs etc)
  • Strong knowledge of RNA biology and/or chemically modified RNAs.
  • Knowledge of drug discovery or pharmaceutical development

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date.

This role is open from 23/02/2022, we welcome your application no later than 09/03/2022.

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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