Do you have expertise in and passion for bioanalytical sciences within Oncology? Would you like to apply your expertise to impact the development of assays and analytical methodologies needed to study payloads, linkers and conjugation technology for the next generation of ADCs? We have an exciting opportunity for you to join the Oncology Bioscience group in London as a laboratory based scientist. You will become part of a large team of scientists and play a pivotal role in the delivery of robust and high quality data to support drug discovery projects within the Oncology portfolio. Working collaboratively with other disciplines across AstraZeneca, you will have the opportunity to contribute to the development of early phase projects. You’ll have a good understanding of the range of procedures relating to bioanalysis/bioscience. You will expertly design and conduct experiments, develop methods, generate, interpret and report scientific data. You will use your scientific judgement, ability to analyse data, lab experience and communication skills to contribute to experimental design and interpretation for early stage drug discovery programmes.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. Here you’ll have the chance to define a difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and crafting the patient ecosystem. With our pipeline, the outlook is forward-thinking. Be proud to be an employee of a place that has achieved so much, yet is still moving forward. It’s time to join our global, growing enterprise as we own the way for healthcare and society.

Site description

Welcome to our Spirogen site, part of the AstraZeneca Group – Whitechapel, London… one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s significant to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you After-work events, Lunch & Learns, spacious office working environment, Networking events. Situated in the heart of London’s historical east end close to the fashionable areas of Shoreditch, Spitalfields and Brick Lane with excellent public transport links to central London.

Business area

Join us in fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our game-changing pipeline. We deliver this value through launch excellence, commercial efficiency and improving the lifecycle. By using our commercialised portfolio we are confident we can change the practice of medicine and redefine cancer treatment.

What you’ll do

AstraZeneca are seeking a highly skilled analytical scientist to work in our Tumour Targeted Delivery team. Based in the Spirogen laboratories in London, you will be an integral member of the analytical team focusing on the rational design of the assays and analytical methods required to study our new payloads, linkers and antibody drug conjugates (ADCs). ADCs are among the fastest growing drug classes in oncology.

  • Independently design and execute assays and use analytical techniques to study small molecules and ADCs

  • Perform routine/QC analysis of small molecules and ADCs

  • Work independently within a team and collaboratively with internal and external stakeholders to ensure the efficient relay of information

  • Communicate results to team members in a clear and concise manner

  • Be involved in the interpretation of data with little or no guidance with a clear understanding of its implications within drug discovery

  • Maintain a well-developed understanding of analytical techniques applying a broader functional knowledge to support the team

  • Regularly share relevant external published papers with peers

  • Ensure own work, and the work of others, is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Laboratory Practice (GLP)

Essential for the role

  • Ph.D and/ or M.Sc in Chemistry, Biochemistry, Chemical engineering or relevant discipline

  • B.Sc in above disciplines with extensive experience in LC-MS and assay developmen

  • Hands-on experience in bioanalysis and LC-MS/MS for measurement of proteins and small molecules

  • Experience in development and application of quantitative bioanalytical methods for small molecules and proteins

  • Deep understanding of chemistry and protein biochemistry

  • Strong multi-tasking, time management and organisational skills

Desirable for the role

  • Experience with Thermo QExactive or Orbitrap Exploris

  • Experience with other analytical technologies (e.g. SEC, HIC, CAD) and automation

  • Experience with programming languages such as R and Python

  • Understanding the process of successful drug discovery/drug development

Why AstraZeneca?

At AstraZeneca, we ‘re nominated to being great Place to Work. Where you are empowered to push the boundaries of science and ignite your entrepreneurial spirit. There’s no better place to make a difference in medicine, patients and society. An expansive environment that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on a pivotal journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already thinking of joining AstraZeneca? Good, because we can’t wait to hear from you.

  • Are you ready to bring new insights and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.

  • If you’re curious to know more please apply today!

Competitive salary package and benefits

Close Date: 28th March 2022

“As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results – pymetrics will not be used solely in our decision-making process but will help us gather additional insight.”

Where can I find out more?

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