Do you have expertise in, and a passion for antibody discovery and protein engineering ? would you like to apply your expertise to impact AstraZeneca’s next-generation biotherapeutics portfolio ; in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

Site description

Welcome to Granta Park Cambridge, one of over 400 sites here at AstraZeneca! Providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you. Cambridge is one of the most exciting bioscience hotspots in the world and plays a central role in our mission to deliver life-changing medicines to patients Granta Park has a gym, nursery and central restaurant/coffee place as part of the science park facilities that are accessible to our staff. We also have our own bistro and deli in the AZ buildings. There are regular lunch & learn events including running clubs and after work socials on the last Friday of every month. This is our biggest and most spacious lab site with easy access from all major routes and ample car parking available – come and join us! Please be aware that towards the end of 2022 you will be required to move the our new state of the art Cambridge Biomedical Centre.

Business area

In the Oncology Business Unit we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease.

Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, challenging accepted norms, quick decision-making and taking smart risks. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp.

What you’ll do

We are currently looking for someone who has a good understanding and experience of the skills required for antibody discovery and protein engineering to support delivery of our next-generation biotherapeutics portfolio. In this role you will craft, lead and conduct laboratory projects/experiments, develop methods, generate, interpret and report scientific data and you will be more than proficient in trouble shooting and theory.

  • Independently defines objectives, leads the planning and execution of complex experimental work to isolate and optimise biologics (e.g. mAbs) for multiple drug discovery projects and/or technology development projects

  • Responsible for the isolation and optimisation of biologics, using in vitro and in vivo technologies, may perform biochemical/cell-based assays

  • Contributes expertise to multi-disciplinary research drug discovery/technology project teams, effectively communicating forward-looking recommendations and contributes to project team decisions based on their own findings, the findings of others, and factors from outside the company

  • Independently leads, plans, prioritises work activities. Provides decisions and recommendations which consistently advance technologies and projects

  • Establishes internal and external contacts and collaborations within scientific field of value to the business and presents findings at internal (intra- and inter-departmental) project team and function meetings

  • Demonstrates strong interpersonal communication by establishing good working relationships with team and department members and others within the company

Essential for the role

  • PhD with relevant experience or BSc/higher degree with equivalent lab-based experience

  • Extensive experience of antibody isolation and engineering (e.g in vitro display technologies, such as phage display), and characterisation including in vitro biochemical assays (ELISA, WB, SPR (Biacore) or BLI (Octet) and functional cell-based assays

  • Extensive experience in troubleshooting molecular biology (extensive experience in techniques such PCR, plasmid DNA preparations, cloning, side-directed-mutagenesis) and other protein engineering methods and track-record of evaluating and implementing novel technologies

  • Experience with DNA analysis software such as lasargene or geneious prime

  • Experience in protein expression (bacterial and mammalian cells) and purification using AKTA systems

  • Good communication, capable of developing good working relationships with individuals across organisational boundaries and experience working within a team environment

Desirable for the role

  • Display technology experience (phage, yeast or mammalian display technologies)

  • Experience of next-generation biologics development for oncology, e.g. multi-specific mAbs and antibody conjugates such as ADCs, would be desirable

  • Experience of next generation sequencing (NGS)

  • Experience in bioinformatics and data analysis for integrated data systems (such as Spotfire)

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  • If you’re curious to know more then please reach out to Louise Bennett

“As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results – pymetrics will not be used solely in our decision-making process but will help us gather additional insight.”

Competitive salary package and benefits

Close Date: 07/11/2021

Where can I find out more?

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