Senior Scientist – Continuous Processing

Senior Scientist – Continuous Processing

Location: Macclesfield

Competitive salary and benefits

Make a positive impact, in a team where it means more

In Operations we have a big ambition – to deliver more medicines to patients, quicker and more affordably. Backed by the investment, leadership and a clear plan to get there, we bring personal dedication and out of the box thinking.

We are driven by our commitment to deliver accelerated growth for AstraZeneca and to make people’s lives better. It pushes us to keep building on our foundations and progressing as we turn our ever-growing and increasingly complex pipeline from molecule to medicine. Be part of evolving how we work with Lean, cutting-edge science, digitalisation and sustainable practices.

Chemical Development:

In Chemical Development we are determined to push the boundaries of science to deliver medicines to our patients.

We combine people’s technical knowledge and understanding with their talent and drive to design, develop and optimise synthetic routes and processes that deliver the active pharmaceutical ingredients of our medicines in a sustainable, commercially viable way.

We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the newest technologies and principles in the processes we develop.

We now have an exciting opportunity for a Senior Scientist in our continuous manufacturing team.

Key responsibilities:

As a continuous flow chemist you will be working in a group dedicated to identifying, developing and delivering continuous manufacturing opportunities in the manufacture of active pharmaceutical ingredients (APIs).

The role involves working collaboratively with chemists, engineers, analysts, machine learning specialists, physical organic scientists and others. In the role you will:

  • Identify, develop and implement new continuous processes suitable for manufacture

  • Be responsible for optimising continuous manufacturing processes taking consideration of speed, quality, cost, sustainability, reproducibility and efficiency

  • Collaborate closely with other scientists to contribute to the development of new medicines

  • Assess and manage process risks arising from scale, equipment or process changes

  • Support problem solving when development or manufacturing issues arise

  • Work with third party organisations to develop and manufacture API processes

  • Contribute to the further development and delivery of a continuous manufacturing strategy for AZ

Essential Requirements:

  • A PhD in Organic Chemistry, or BSc/MSc or relevant industrial experience to an equivalent level

  • Substantial experience in practical organic synthesis

  • A proven record of innovation through, for instance, authorship of papers, inventor status on patents, or presenting at external conferences

  • An excellent understanding of synthetic reagents and methodologies, reaction mechanisms and modern analytical techniques

  • The ability to think innovatively and be open minded to applying new technologies when finding solutions to long term API manufacture.

Desirable Requirements

  • Lab-based pharmaceutical industry and/or process development experience, using a broad range of practical techniques

  • Practical experience of continuous flow chemistry

  • Practical experience of modern synthetic technologies, e.g. process analytical techniques, high through-put experimentation, etc.

  • A substantial and influential record of publication

  • Proven laboratory team leadership skills

  • The ability to develop and analyse multiple solutions to problems

  • The confidence to coach and drive performance and development among your peers

Skills and capabilities

  • Ability to challenge and innovate, bringing new solutions and opportunities for chemical development.

  • Ability to analyse and interpret complex chemistry problems and provide solutions

  • Excellent communication skills, with the ability to communicate across interfaces of scientific subject areas, culture, and expertise both internally and externally.

  • The ability to confidently participate in, and potentially lead, strategic development of technology areas.

Please note applications must include your current CV and a covering letter which presents your key areas of skill and why you should be considered for the role.

Why AstraZeneca…

Join the team where everyone feels a personal connection to the people that we impact. From our science labs to manufacturing at scale, we are committed to delivering at the highest quality. It’s inspiring and rewarding work, influencing every part of the product lifecycle to deliver life-changing medicines. To ultimately make people’s lives better – from patients and their families to all of us in society.

Next steps…

Are you ready to bring new ideas and fresh thinking to the table? Excellent! We have one seat available and we hope it’s yours!

Applications are open from 23rd August to 6th September 2021

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