Do you have expertise in, and passion for, Oncology Research? Would you like to apply your expertise to a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

About AstraZeneca

At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.

Site description

Welcome to Cambridge, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…

Central Cambridge – Located in walking distance from the Train station, you will have access to an onsite gym, restaurant facilities and experience working within a calm and relaxing agile environment, inspired by the University Botanical gardens. You’ll also be able to enjoy Lunch & Learn development activities, all within a forward-thinking and spacious environment while utilising the most advanced technology.

Business area

AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas – breast, ovarian, lung and haematological cancers.

We are seeking a highly motivated Senior Scientist in Immuno-Oncology with deep scientific and technical expertise in adaptive immune cell biology specifically focusing on T cell immunology, with a track record of scientific excellence to join our team in Cambridge, UK. As a Senior Scientist you will be a key member of a team focussed on supporting immune-oncology projects through the drug discovery process. You will bring your theoretical and practical expertise in immunology to establish assay systems and deliver datasets that will have direct impact on immune-oncology research projects.

What you’ll do

Working in this laboratory-based position within the Immuno-Oncology Research group you will develop, design, conduct and analyse in vitro experiments to assess the function of our candidate drugs and help to dissect the mechanism of action of novel therapeutics targeting the immune system for cancer therapy. You will also review emerging literature and internal data to help in identifying new potential targets and contribute to target validation activities. A solid foundation in immunology / immuno-oncology, and depth of expertise in techniques for the analysis of immune function and phenotype is important for this role. As a highly organised, self-motivated individual with a strong lab/practical background you will stay up to date with relevant technical and intellectual scientific expertise in tumour immunology and have a genuine passion for this field of research.

Essential for the role

  • A PhD, or equivalent experience, in immunology and/or immuno-oncology.

  • Deep expertise in T cell immunology plus broad understanding and enthusiasm for translating basic science into novel cancer therapies

  • Deep expertise working with immune cells and in vitro / ex vivo co-cultures to determine immune function

  • Experience of a range of in vitro skills for the analysis of human immune cell function e.g. multiparameter flow cytometry and analysis using dimensionality reduction, ELISA, molecular biology skills including transcriptomics, single cell sequencing, assessment of intracellular signaling and generation of engineered cell lines

  • Strong interpersonal, influencing, negotiating and collaboration skills together with evidence of having used these to support problem solving and delivery in a team-oriented, collaborative environment.

  • Depth of understanding and passion for immunology and immuno-oncology

  • Consistent track record of success in your research

  • Data processing, statistical analysis and interpretation.

  • Experience preparing written scientific reports (e.g. manuscripts) and oral presentations (e.g. slides, posters).

Desirable for the role:

  • Experience with protein engineering and antibody design

  • Expertise in field of T cell exhaustion

  • Experience with visualizing/quantitating high content multi-parameter flow data and evaluation of transcriptomic datasets

  • Experience working with patient-derived tumours/organoids/TILs an advantage

  • Knowledge of the drug discovery process

  • Publications in top tier scientific journals

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you. Don’t hesitate in submitting an application today!

Competitive salary and benefits package on offer.

The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.

Closing date: 1st January 2022

Where can I find out more?

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We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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