Senior Scientist – Molecular and Cellular Biology

We are seeking a highly motivated Senior Scientist with broad molecular and cellular biology skills and a track record of scientific achievement to join our Delivery Systems Safety team in Cambridge, UK.

Senior Scientist – Molecular and Cellular Biology, Safety Science

Cambridge, UK

Competitive Salary & Benefits

Make a more meaningful impact to patients’ lives around the globe

Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

Follow the science to explore and innovate

Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world’s most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world!

What you’ll do

An exciting opportunity now exists to join our Delivery Systems Safety Team to help drive the development of safe and innovative RNA vaccines for protection against pathogens. We use innovative molecular and cellular biology technologies and in vitro, ex vivo and in vivo models to develop tailored solutions to assess potential safety concerns associated with delivery systems for gene therapies and vaccines.

We are seeking a highly motivated Senior Scientist with broad molecular and cellular biology skills and a track record of scientific achievement to join our Delivery Systems Safety team in Cambridge, UK.

As a Senior Scientist, you will be a key member of a team focussed on supporting safety studies in RNA vaccines. You will bring your theoretical and practical expertise in RNA and protein biology to establish cell and molecular assay systems, conduct research and deliver datasets that will directly impact our portfolio. A scientist who will stay up to date with relevant technical and intellectual scientific expertise in molecular and cellular biology is also strongly desired.

Responsibilities

Working in this laboratory-based position within the Delivery Systems Safety research group you will:

  • Develop and conduct vitro and in vivo experiments to improve our understanding of the safety of self-amplifying RNA (saRNA) technology, including assessing the global effects of saRNA on host cells
  • Be a subject matter expert and review emerging literature and internal data to help in identifying new potential technologies and approaches for RNA and protein detection
  • A solid foundation in Molecular Biology and Biochemistry is crucial for this role.

Essential Requirements

  • A PhD, or equivalent experience, in nucleic acid delivery systems and vaccine development or gene therapy, with 1-3 years of post-doctoral experience in a relevant research area.
  • Strong hands-on skills in molecular biology methods, including nucleic acid extraction and standard DNA/RNA detection techniques (PCR, qPCR and ddPCR).
  • Expertise in biochemical methods (Western blot, immunoprecipitation, ELISA and colourimetric assays)
  • Experience in cell-based assays, including functional assays, flow cytometry and multiplex RNA/protein detection (e.g. in situ hybridisation and immunofluorescence)
  • Passionate about assay development and an ability to learn new techniques quickly
  • Knowledge and practical experience in aseptic techniques and mammalian cell culture
  • Delivery attitude and ability to work in a fast-paced environment with changing priorities, plan and meet timeline
  • Proven success in researching and preparing written scientific reports, publications and oral presentations

Desirable Requirements

  • Hands-on experience in RNA: protein interaction methodologies
  • Proficiency in Omics methods (transcriptomics and proteomics) and data analysis
  • Experience in multiple imaging platforms, particularly in the context of RNA localisation
  • Experience working with iPSCs-derived and primary cells would be an advantage, but not essential
  • Knowledge and experience in immunology and cellular stress pathways

Why AstraZeneca?

At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date.

This role is open from 18/02/2022, we welcome your application no later than 04/03/2022.

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

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