Do you have expertise in, and passion for, oncolytic virus drug development; with a track record of scientific excellence? Would you like to apply your expertise to positively impact our Tumour Targeted Delivery Group in a company that follows the science and turns ideas into life changing medicines? Then joining AstraZeneca might be the right career choice for you! As a Senior Scientist you will be a key member of a team focussed on supporting the development of novel oncolytic viral drug therapies.

ABOUT ASTRAZENECA

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

SITE DESCRIPTION

The successful candidate will be based in Granta Park Cambridge, UK, one of over 400 sites here at AstraZeneca. This site provides a collaborative environment where everyone feels comfortable and able to be themselves and bring their full selves to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you… Granta Park has a newly built gym with swimming pool, nursery and central food hub accesible to staff as part of the science park facilities. We also have our own bistro and deli in the AstraZeneca buildings. There are regular ‘Lunch & Learn’ events and after work socials with snacks and drinks on the last Friday of every month. This is our biggest and most spacious lab site in Cambridge…come and join us!

BUSINESS AREA

Join the team dedicated to Oncology, with an ambition to eliminate cancer as a cause of death. It’s our big vision that unites and inspires us. With multiple priority indications within oncology and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward with cutting-edge science with the latest technology to achieve breakthroughs. Astra Zeneca is a company built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, we invite you to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team. The successful candidate will help our oncology group expedite our oncolytic virotherapy research in some of the hardest-to-treat cancers, and will have the opportunity to build a rewarding and meaningful career as part of the team committed to improving the lives of millions with cancer.

What you’ll do

In this role you will join a team of in vitro and in vivo virologists/biologists in the Oncolytic Virotherapy group to support oncolytic virus (OV) programs in AstraZeneca’s Early Discovery portfolio. You will design, produce, and characterize next generation OVs with improved therapeutic potential. You will be accountable for the delivery of data to develop new pipeline projects, and requires in vitro expertise in cell biology, molecular biology, and protein biochemistry techniques. The successful candidate will be expected to spend the majority of their time in the lab performing in vitro experiments working with OVs and human cancer cell lines as well as primary ex vivo human or mouse tumor samples. You will serve as an expert in the field of OVs with the expectation to eventually mentor and develop direct reports or other colleagues within our Oncology department. You will be given the opportunity to present research findings internally and at external meetings, publish in peer-reviewed journals and contribute to patent filings. Finally, you will interact and collaborate with AstraZeneca science leaders across disciplines to guide the strategic direction for our OV portfolio.

Essential for the role

  • Ph.D., PharmD or equivalent advanced degree in Molecular Virology, Microbiology, Cell Biology, Oncology or a related field.

  • Experience with a range of in vitro and ex vivo cell biology skills relevant to virology, cancer biology, and/or immunology. May include expertise in a range of tissue culture techniques including culture of ex vivo tissue explants, human and mouse immune cell characterization, and analytical methods such as multi-parametric flow cytometry, ELISA, qPCR, and cell viability assays.

  • Highly developed problem solving and time management skills.

  • Effective communication skills and experience in delivering oral presentations and written reports.

  • Excellent team player with good interpersonal skills, able to work collaboratively across teams.

Desirable for the role

  • Recognized contributor in oncolytic virology, or related field, as evidenced by a strong publication record in peer-reviewed journals.

  • Experience within the pharmaceutical/biotech industry and the drug discovery process and/or academic experience with viruses as therapeutics (oncolytic viruses, viruses as vectors or vaccine platforms).

  • Knowledge and hands-on experience in the design, engineering, production, isolation and characterization of novel recombinant viruses, which may include oncolytic viruses.

  • Hands on experience in mining and interpretation of biological datasets such as RNAseq, TCGA, or other open-source or in-house genomic datasets.

  • Experience in immunology and immuno-oncology, including the combination of oncolytic virotherapy with immunotherapies or other standard-of-care therapies.

Competitive salary & benefits

Close date: 21/11/2021

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. We have an inclusive culture that champions diversity and collaboration, and is always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  • If you’re curious to know more then please reach out to Louise Bennett

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

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“As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results – pymetrics will not be used solely in our decision-making process but will help us gather additional insight.”

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