Senior Scientist, Targeted Tumor Delivery, Oncology R&D

Do you have expertise in, and passion for, Targeted Tumor Delivery with deep scientific and technical expertise in antibody/antibody-drug conjugate therapeutics with a track record of providing scientific excellence? Would you like to apply your expertise to impact the Oncology R&D department in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

ABOUT ASTRAZENECA

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

SITE DESCRIPTION

Welcome to Waltham, MA one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…Our Waltham, MA facility builds life-changing medicines for people around the world. The modern, vibrant scientific campus employs more than 800 experts in our field, and it is only a short drive from Boston, MA. It is filled with cutting edge technology. Our work areas were built to facilitate teamwork, interaction and cross functional science. We believe employees benefit from being challenged and inspired at work. The Boston R&D site located in Waltham, MA is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech startups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space. Site amenities include:

Modern 64-acre campus nestled in 200+ acres of nature conservation land & hiking trails, flexible, agile lab design with co-located write-up space, vibrant site community with activities, clubs, sports & games, onsite business & meeting center, office, AV & catering support.

BUSINESS AREA

Join a dedicated Oncology team that’s growing fast and building a strong track record of success. Our pioneering approach is identifying and treating patients earlier, focusing on early stage cancer trials and listening and evolving based on their needs. As a team we are deeply committed to transforming the lives of patients living with cancer – with the ultimate aim of eliminating cancer as a cause of death. Since our renewed focused on building our Oncology function, we have had great successes with 7 new Oncology medicines since 2013. We set the tone for the rest of the industry, consistently publishing our findings in high impact journals, and leading with expertise and entrepreneurial spirit. And we continue to push forward – in 2019 we invested $6.1bn in Research & Development.

What you’ll do

  • Working in this laboratory-based position within the Oncology Research group you will independently utilize solid tumor PDX models to develop, design, conduct and analyze in vivo and ex vivo drug discovery research experiments. You will be responsible for communicating the results to team members and leadership groups. You will also review emerging literature and internal data to identify and credential new targets and contribute to target validation activities.

  • Serve as the ‘In Vivo Lead’ for high-profile clinical assets whereby you will have the opportunity to work with late-stage development colleagues, influence clinical development and identify new opportunities (e.g. indication expansion, combinations).

  • As a highly organized, self-motivated individual with a strong laboratory science background you will stay up to date with relevant technical and intellectual scientific expertise in antibody therapeutics, cancer biology & tumor immunology and have a genuine passion for this field of research.

Essential for the role

  • Master’s degree with a focus on cancer biology, pharmacology and/or immunology

  • A strong foundation in antibody therapeutics (preferably antibody-drug conjugates) and in-depth expertise in techniques for assessing their pharmacodynamic properties in in vivo systems

  • Extensive experience working with solid tumor PDX models and performing n=1 study designs ((syngeneic murine tumor models a plus)

  • Molecular biology and biochemistry skills (e.g. qPCR, western blotting, ELISA)

  • Genetic modification of cell lines and/or primary cells (e.g. shRNA, CRISPR)

  • Strong interpersonal, influencing, negotiating and collaboration skills together with evidence of having used these to support problem solving and delivery in a team-oriented, collaborative environment

Desirable for the role

  • PhD with cancer biology, pharmacology, immunology or immuno-oncology focus is preferred

  • Lead in vivo efforts for multiple drug discovery programs (preference for antibody, ADC and IO)

  • A foundation in immunology / immuno-oncology, and expertise in techniques for the analysis of immune function and phenotype

Why AstraZeneca?

Join the team dedicated to Oncology, with an ambition to eliminate cancer as a cause of death. It’s our big vision that unites and inspires us. With multiple indications and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward. Fusing cutting-edge science with the latest technology to achieve breakthroughs. Backed by investment, we are aiming to deliver 6 new molecular entities by 2025. A place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team. Pioneers of collaborative research we have built an unrivalled scientific community both internally and externally. Fusing academia and industry, we have united some of the world’s foremost medical centres. Working seamlessly and inclusively, together we expedite research in some of the hardest-to-treat cancers. Have the opportunity to build a rewarding and meaningful career as part of the team committed to improving the lives of millions with cancer.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  • If you’re curious to know more then please reach out to Louise Bennett.

Competitive salary package and benefits

Close Date: 23/05/2021

Where can I find out more?

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