Senior Scientist, Translational Medicine (16 month contract)

We are seeking a Senior Scientist for a 16 month fixed-term contract to join the Oncology Translational Medicine group. A world-class centre for discovery and development of innovative cancer medicines; based at the heart of the Cambridge UK biomedical research community, at the forefront of the evolution of translational science for the global oncology group at AstraZeneca. You will have the opportunity to impact an industry-leading portfolio of programs from early clinical development of novel therapeutics through post-marketing opportunities that support approved targeted therapies.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

Site description

Cambridge Science Park is one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site and park provides for you… After-work events, Lunch & Learns, Bright and spacious environment, Sustainable office working environment, Onsite Childcare, Networking events, Park site Hair & Beauty Salon, Gym and Restaurants.

Business area

From diagnosis to later stage development, we’re laser-focused on leading the way forward to create solutions that transform lives. We are focused on identifying and treating patients earlier, where there is greater curative potential. With the greatest number of early stage cancer trials in the industry, we are getting closer to finding cures every day.

It is the breadth and strength of our innovative pipeline that offers both security and stability. And with the goal to deliver 6 new molecular entities by 2025, it’s up to each of us to keep pushing our industry-leading Oncology pipeline forward and build the future

What you’ll do

  • As a laboratory-based senior scientist your focus is to deliver biomarker data on clinical trial samples based on the best available science and technologies.

  • Generating disease linkage data to guide indication selection and targeted patient populations.

  • You will be measuring target engagement reliably and quantifiably to advise clinical decisions for selecting therapeutically relevant doses and schedules.

  • You will understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations.

  • You will provide expert interpretation of the data, identifying innovative solutions to problems and putting forward plans for future biomarker assays.

Essential for the role

  • PhD or master’s degree with expertise in a relevant field.

  • Experience in protein analysis and proteomics methods.

  • Strong experience in molecular and cell biology, with experience in assay development for new biomarkers.

  • Experience in working with peripheral blood and isolation of its components and/or on developing assays in peripheral blood mononuclear cells.

  • Experience in molecular pathology/cancer biology and peer-reviewed publications in the field of molecular pathology/cancer biology.

  • Experience of conducting studies for Good Clinical Practice (GCP).

  • Ability to lead from the bench in problem solving and the development of innovative solutions.

  • Ability to collaborate with colleagues both within Translational Medicine and across multidisciplinary teams and able to work well within group environments.


  • Career exposure to the pharmaceutical industry and the drug development process.

  • Expertise in one or more AZ portfolio areas: DNA damage and repair, tumour drivers and resistance, hormone receptor signalling, epigenetics

  • Experience in circulating tumour cell analysis.

  • Experience of in situ hybridization and other RNA-based methods such as NanoString or Digital Spatial Profiling.

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  • If you’re curious to know more then please reach out to Louise Bennett

Competitive salary package and benefits

Close Date: 19/07/2021

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