The Translational Pathology team works within translational medicine to leverage actionable insights through the investigation of molecular and histological features of patient tissues. We are recruiting for a lab-level scientist to join the growing multiplex immunofluorescence laboratory in either Gaithersburg US or Cambridge UK to develop new multiplex IF panels for immune profiling, discovery, and description of determinants of response and resistance to immune therapies.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

Business area

In the Oncology Business Unit we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease.

Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, challenging accepted norms, quick decision-making and taking smart risks. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp.

What you’ll do (site location Gaithersburg US or Cambridge UK)

  • Develop, validate, and deploy multiplex immunofluorescence panels for human clinical trial samples.

  • Work across oncology translational medicine (TM) in a dynamic matrix environment to identify and address most impactful challenges to facilitate safe, rapid, and effective understanding of molecular mechanisms in oncology.

  • Discover, test, and improve commercial and noncommercial multiplex IF staining and imaging platforms

  • Drive the development of novel image analysis solutions.

  • Work closely in collaboration with machine learning engineers inside AZ to develop new methods of data analysis suitable for the multi-parametric datasets in multiplex IF.

  • Apply data and knowledge analytics to deliver actionable insight driving discovery and development of the next generation of cancer medicines.

  • Discover, design and code innovative ways to identify and visualize meaningful patterns in complex data.

  • Work with our labs to influence generation of data assets.

  • Collaborate with industry and academia.

  • Publish your work in high impact journals.

Essential for the role

  • Relevant PhD (or equivalent graduate degree plus proven applied experience), combining:

  • Technical experience in the design, development, and validation of multiplex IF panels (4+ markers, any method)

  • Multiplex immunofluorescence imaging experience.

  • Image analysis experience.

  • Technical expertise in pathology, histology, immunohistochemistry, image analysis, biostatistics, mathematical modelling, and data science.

  • A deep understanding of the molecular mechanisms driving cancer or immunological disorders.

  • Innate drive to identify, understand, and resolve impediments to achieving goals.

  • Skilled in effective communication of complex data to a non-expert.

  • Data management including curation, data engineering, FAIR and reproducible research practices.

  • Capability of successfully managing multiple simultaneous projects.

  • Working effectively within cross-disciplinary science teams, including with functional leaders.

  • Experience contributing to the research community through publications and presentations

  • R and/or Python programming and visualization expertise desired.

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  • If you’re curious to know more then please reach out to Louise Bennett

Competitive salary package and benefits

Close date 25/10/2021

Where can I find out more?

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